4.

探究肺切除后行胸腔冲洗液细胞学检查预后意义的相关研究

Studies demonstrating the prognostic significance of pleural lavage cytology after lung resection

Author, ref. number, year, type of study	Patient group	Outcomes: survival rate	Other results or comments
Taniguchi et al[13] (2009) Prospective study	Total number of patients: 296 Patients with positive PLC after lung resection: 26 (8.8%)	5-year survival rate for negative PLC vs positive PLC before closure: 76% vs 32% (P＜0.000, 1)	PLC before closure was found to be an independent prognostic factor (P=0.001) in multivariate analysis, in contrast with PLC after thoracotomy (P=0.26)
Shintani et al[8] (2009) Prospective study	Total number of patients: 1271 Patients with positive post-PLC: 32 (2.5%)	Five-year survival rate was 21.9% for patients with positive post-PLC compared to 58.3% for patients with negative post-PLC (P＜0.000, 1)	A significantly higher rate of pleural recurrence was found in patients with positive post-PLC compared to patients with negative post-PLC
Aokage et al[14] (2010) Prospective study	Total number of patients: 2178 Patients with positive post-PLC: 70 (3.2%)	The 5-year survival rate for positive post-PLC vs negative post-PLC: 22% vs 69% (P < 0.001). The5-year recurrence-free survival rate for positive post-PLC vs negative post-PLC: 4% vs 67% for patients with (P < 0.001).	Post-PLC showed a stronger survival impact than pre-PLC. Post-PLC was also a strong predictor of recurrence.
Shoji et al[34] (2016) Prospective study	Total number of patients: 700 Patients with positive post-PLC: 47 (6.7%)	The 5-year OS of patients with positive post-PLC was significantly worse than those with negative pre-PLC (P＜0.000, 1). The RFS was similarly worse for patients with positive post-PLC status regardless of pre-PLC findings (not significant).	Differences between the RFS according to post-PLC status were greater than those according to the pre-PLC status. Multivariate analysis of RFS revealed that post-PLC status (P=0.009, 0) is an independent prognostic factor.