Table 1.
Summary of genotyping results for all 23 risk SNPs
| OncoArray | Previous data | Replication | Combined meta | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Locus | Pos. (b37) | Risk Allele | RAF | OR | P trend | OR | P trend | OR | P trend | OR | P meta | I 2 |
| rs7577599 | 2p23.3 | 25613146 | T | 0.81 | 1.22 | 2.63×10−3 | 1.24 | 1.24×10−16 | – | – | 1.23 | 1.29×10−18 | 0 |
| rs4325816 | 2q31.1 | 174808899 | T | 0.77 | 1.16 | 1.23×10 − 2 | 1.11 | 1.30×10 − 5 | 1.16 | 3.00×10 − 3 | 1.12 | 7.37×10 − 9 | 9 |
| rs6599192 | 3p22.1 | 41992408 | G | 0.16 | 1.24 | 1.35×10−3 | 1.26 | 8.75×10−18 | – | – | 1.26 | 4.96×10−20 | 0 |
| rs10936600 | 3q26.2 | 169514585 | A | 0.75 | 1.18 | 5.12×10−3 | 1.20 | 5.94×10−15 | – | – | 1.20 | 1.20×10−16 | 0 |
| rs1423269 | 5q15 | 95255724 | A | 0.75 | 1.09 | 0.125 | 1.17 | 1.57×10−11 | – | – | 1.16 | 8.30×10−12 | 23 |
| rs6595443 | 5q23.2 | 122743325 | T | 0.43 | 1.14 | 9.87×10 − 3 | 1.10 | 4.69×10 − 6 | 1.10 | 0.022 | 1.11 | 1.20×10 − 8 | 0 |
| rs34229995 | 6p22.3 | 15244018 | G | 0.02 | 1.05 | 0.781 | 1.40 | 1.76×10−8 | – | – | 1.36 | 5.60×10−8 | 0 |
| rs3132535 | 6p21.3 | 31116526 | A | 0.29 | 1.26 | 2.67×10−5 | 1.20 | 2.97×10−17 | – | – | 1.21 | 6.00×10−21 | 0 |
| rs9372120 | 6q21 | 106667535 | G | 0.21 | 1.18 | 7.74×10−3 | 1.20 | 8.72×10−14 | – | – | 1.19 | 2.40×10−15 | 0 |
| rs4487645 | 7p15.3 | 21938240 | C | 0.65 | 1.23 | 1.06×10−4 | 1.24 | 5.30×10−25 | – | – | 1.24 | 2.80×10−28 | 0 |
| rs17507636 | 7q22.3 | 106291118 | C | 0.74 | 1.12 | 5.71×10 − 2 | 1.12 | 5.54×10 − 7 | 1.10 | 0.036 | 1.12 | 9.20×10 − 9 | 50 |
| rs58618031 | 7q31.33 | 124583896 | T | 0.72 | 1.17 | 7.61×10 − 3 | 1.11 | 4.70×10 − 6 | 1.10 | 0.061 | 1.12 | 2.73×10 − 8 | 0 |
| rs7781265 | 7q36.1 | 150950940 | A | 0.12 | 1.33 | 3.23×10−4 | 1.20 | 1.82×10−7 | – | – | 1.22 | 4.82×10−10 | 49 |
| rs1948915 | 8q24.21 | 128222421 | C | 0.32 | 1.19 | 1.68×10−3 | 1.14 | 3.14×10−10 | – | – | 1.15 | 2.53×10−12 | 26 |
| rs2811710 | 9p21.3 | 21991923 | C | 0.63 | 1.13 | 1.76×10−2 | 1.14 | 6.50×10−10 | – | – | 1.14 | 3.64×10−11 | 0 |
| rs2790457 | 10p12.1 | 28856819 | G | 0.73 | 1.09 | 0.124 | 1.12 | 8.44×10−7 | – | – | 1.11 | 2.66×10−6 | 0 |
| rs13338946 | 16p11.2 | 30700858 | C | 0.26 | 1.17 | 7.90×10 − 3 | 1.12 | 2.22×10 − 7 | 1.26 | 2.5×10 − 7 | 1.15 | 1.02×10 − 13 | 26 |
| rs7193541 | 16q23.1 | 74664743 | T | 0.58 | 1.14 | 9.01×10−3 | 1.12 | 1.14×10−8 | – | – | 1.12 | 3.68×10−10 | 34 |
| rs34562254 | 17p11.2 | 16842991 | A | 0.10 | 1.32 | 7.63×10−4 | 1.30 | 3.63×10−17 | – | – | 1.30 | 1.18×10−19 | 29 |
| rs11086029 | 19p13.11 | 16438661 | T | 0.24 | 1.26 | 1.02×10 − 4 | 1.12 | 1.69×10 − 6 | 1.15 | 5.00×10 − 3 | 1.14 | 6.79×10 − 11 | 42 |
| rs6066835 | 20q13.13 | 47355009 | C | 0.08 | 1.13 | 0.162 | 1.24 | 1.16×10−9 | – | – | 1.23 | 6.58×10−10 | 38 |
| rs138747 | 22q13.1 | 35700488 | A | 0.66 | – | – | 1.21 | 2.58×10−8 | – | – | 1.21 | 2.58×10−8 | 0 |
| rs139402 | 22q13.1 | 39546145 | C | 0.44 | 1.11 | 4.146×10−2 | 1.23 | 4.98×10−26 | – | – | 1.22 | 3.84×10−26 | 56 |