Table 2.

A breakdown of the primary biological functions and canonical pathways that were regulated in both a circadian manner and in response to phosphate deficiency.

Canonical Pathways	−log10(p-value)	Diseases or Functions Annotation	−log10(p-value)
Mitochondrial Dysfunction	13.2	cell death	13.88
Oxidative Phosphorylation	11.6	necrosis	13.64
Protein Ubiquitination Pathway	10.2	organismal death	12.01
NRF2-mediated Oxidative Stress Response	4.62	morbidity or mortality	11.72
Glutaryl-CoA Degradation	4.61	apoptosis	10.49
PTEN Signaling	4.43	cell death of connective tissue cells	8.39
Aldosterone Signaling in Epithelial Cells	4.22	size of embryo	7.68
Apoptosis Signaling	4.17	cell death of fibroblast cell lines	6.69
Huntington’s Disease Signaling	4.04	processing of RNA	6.23
Hypoxia Signaling in the Cardiovascular System	4.01	necrosis of muscle	6.12
PI3K/AKT Signaling	3.75	Growth Failure	6.01
STAT3 Pathway	3.35	morphology of body cavity	5.68
Rac Signaling	3.28	morphology of heart	5.66
TCA Cycle II (Eukaryotic)	3.18	neuronal cell death	5.66
IGF-1 Signaling	3.16	omphalocele	5.59
B Cell Receptor Signaling	3.14	morphology of cardiovascular system	5.46
Ephrin Receptor Signaling	3.07	arrest in G2 phase of fibroblast cell lines	5.23
Regulation of eIF4 and p70S6K Signaling	3.04	interphase	5.23
NF-κB Signaling	3.03	proliferation of connective tissue cells	5.03
Glucocorticoid Receptor Signaling	2.99	anemia	5.03

A set of 1,879 genes that were significantly associated with diet and also reported as having a circadian pattern of regulation in mouse calvaria was used to perform functional annotation in Ingenuity Pathway Analysis.