Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Immunomodulatory properties of TLR7 agonists, conjugates and liposomes.
| Sample | EC50 nM | MEC nM | |
|---|---|---|---|
| Conjugates | Unconjugated TLR7 Agonist (8) | 483 ± 25 | 74 |
| Unmodified TLR7 Agonist (9) | 620 ± 19 | 190 | |
| DOPE-TLR7a + DMSO | 9 ± 1 | <1 | |
| DOPE-TLR7a − DMSO | No activity (>2000 nM) | No activity (>2000 nM) | |
| Liposomes | MLV 1% DOPE-TLR7a | 45 ± 23 | 6 |
| MLV 20% DOPE-TLR7a | 34 ± 20 | <2 | |
| MLV 20% DOPE-TLR7a + TDB | 33 ± 19 | <2 | |
| MLV + TDB | 223 ± 173 | <24 | |
| MLV no immunostimulatory agent | >200,000 | >200,000 |
