Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 7;9:1930. doi: 10.3389/fimmu.2018.01930

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Ruytinx, Proost, Van Damme and Struyf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of chemokines involved in recruitment, differentiation and positioning of TAMs. Tumor-derived factors such as the chemokines CCL2, CCL3, CCL4, CCL5, CCL18, CCL20 actively recruit (red arrow) monocytes to the tumor, where they differentiate into tumor-associated macrophages (TAMs). In addition to several growth factors, a particular role in TAM polarization (blue arrow) has been described for the chemokines CCL2, CXCL12 and the chemokine-like protein MIF. In hypoxic areas, higher amounts of CXCL12 and increased expression of CXCR4 on macrophages enhance migration to and retention in these particular sites with low oxygen tension.