Table 1.
Antimicrobial activity of asiatic acid, vancomycin, and metronidazole against C. difficile isolated from different sources.
| Strains | MIC (μg/ml) |
MBC (μg/ml) |
Sources | ||
|---|---|---|---|---|---|
| Asiatic acid | Vancomycin | Metronidazole | Asiatic acid | ||
| R20291 | 10.0 | 1.0 | 0.5 | 10.0–20.0 | Human |
| 630 | 10.0–20.0 | 2.0 | 0.5 | 10.0–20.0 | Human |
| Fd001 | 10.0 | 8.0 | 16.0 | 10.0 | Food |
| Fd002 | 10.0 | 4.0 | 8.0 | 10.0 | Food |
| Fd003 | 10.0 | 2.0 | 8.0 | 10.0 | Food |
| Bv001 | 10.0 | 2.0 | 8.0 | 10.0 | Animal |
| Bv002 | 10.0 | 2.0 | 8.0 | 10.0 | Animal |
| Sw001 | 10.0 | 4.0 | 8.0 | 10.0 | Animal |
| Ct001 | 10.0 | 2.0 | 8.0 | 10.0 | Animal |
| RA037 | 10.0 | 4.0 | 2.0 | 10.0 | Human |
| RA044 | 10.0 | 1.0 | 0.5 | 10.0 | Human |
| RA156 | 10.0–20.0 | 1.0 | 1.0 | 10.0–20.0 | Human |
| RA376 | 10.0 | 1.0 | 1.0 | 10.0 | Human |
| NIH001 | 10.0 | 1.0 | 1.0 | 10.0 | Human |
| NIH011 | 10.0 | 2.0 | 1.0 | 10.0 | Human |
| NIH017 | 10.0 | 8.0 | 4.0 | 10.0 | Human |
| NIH028 | 10.0 | 8.0 | 16.0 | 10.0 | Human |
| NIH042 | 10.0 | 4.0 | 16.0 | 10.0 | Human |
| NIH031 | 10.0 | 2.0 | 16.0 | 10.0 | Human |
At least 3 biological replicates were performed to ensure the reproducibility.