Table 2.
Parasite Density Dynamics Assessed Through Poisson Regression Random-Effect Models of the Geometric Mean Parasite Density Variations Through Time, and Kaplan–Meier Half-Life Clearance Estimates of the Probability of Failure to Reduce the Initial Parasitemia by Half by Day 28 of Follow-up
| Day | Positive by PCR (No.)a | Poisson Regression Random-Effect Model |
Kaplan–Meier Half-Life Clearance |
||
|---|---|---|---|---|---|
| Geometric Mean Parasitemia by qPCR (95% CI) | Risk Ratio (95% CI) | Half-Life Clearance (LFU) | Cumulative Probability of Failure, % (95% CI) | ||
| 0 | 31 (31) | 511.1 (279.1–935.9) | 1 | ||
| 1 | 31 (31) | 208.5 (101.0–430.6) | 0.41 (.39–.41) | 10 (0) | 0.69 (.49–.81) |
| 2 | 28 (30) | 120.2 (51.3–281.8) | 0.31 (.30–.31) | 2 (2) | 0.63 (.44–.58) |
| 3 | 26 (28) | 81.9 (39.8–168.6) | 0.18 (.18–.19) | 1 (0) | 0.59 (.40–.74) |
| 7 | 22 (24) | 66.4 (28.5–154.6) | 0.14 (.14–.14) | 2 (1) | 0.52 (.33–.68) |
| 14 | 24 (26) | 53.6 (24.2–118.8) | 0.09 (.08–.09) | 3 (0) | 0.41 (.23–.58) |
| 21 | 18 (22) | 30.4 (12.2–76.0) | 0.05 (.05–.05) | 3 (0) | 0.30 (.14–.47) |
| 28 | 21 (25) | 56.7 (18.3–175.4) | 0.29 (.29–.30) | 2 (1) | 0.22 (.09–.39) |
Abbreviations: CI, confidence interval; LFU, lost to follow-up; PCR, polymerase chain reaction; qPCR, quantitative polymerase chain reaction.
aThree individuals had missing qPCR data (on days 0, 1, and 21, respectively), and 9 skipped 1 day of follow-up (1 on day 2, 1 on day 3, 4 on day 7, and 3 on day 21).