Figure 2.

Derivation of target concentration to prevent parasitemia during pregnancy. A, Raw population piperaquine (PQ) levels at loop-mediated isothermal amplification (LAMP)–positive or LAMP-negative visits. B, Increasing raw population PQ levels (stratified into 5 categories) associated with lower probability of LAMP positivity during pregnancy. Marginal estimates were derived using mixed-effects logistic regression, accounting for repeated observations within individuals (below the limit of quantitation [BLQ] of 0.5 ng/mL). C and D, Modeled trough PQ levels of 10.3 and 13.9 define upper bounds of uncertainty for 95% and 99% protection from malaria infection during pregnancy, respectively. Abbreviations: LAMP, loop-mediated isothermal amplification; PQ, piperaquine.