Figure 3.

Increasing piperaquine (PQ) exposure associated with improved outcomes at birth. A, Days above target PQ concentration among women randomized to dihydroartemisinin-piperaquine every 4 weeks vs every 8 weeks. Probability of placental malaria (B and C), preterm birth (D), and low birth weight (E) modeled over time above target PQ concentration. Red line represents probability of outcome at delivery among women randomized to intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine. Similar results obtained with cumulative area under the curve (AUC) and cumulative AUC above target. Abbreviations: LAMP, loop-mediated isothermal amplification; q4week, every 4 weeks; q8week, every 8 weeks.