Table 2.
Impact of Different Regimens on Probability of Delivery Outcomes
| Regimen | Delivery Outcome | |||||
|---|---|---|---|---|---|---|
| PQ Dosing Regimen | Loading Dose (Standard Treatment Dose) |
Frequency | Probability of Positive LAMP | Probability of Positive Histopathology | Probability of Low Birth Weight | Probability of Preterm Birth |
| Woman with typical (median) PQ clearance | ||||||
| 2880 mg + 160 mg QD (day 3) | Yes | Daily | <0.01 (<.01–.15) | 0.12 (.05–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 2880 mg + 160 mg QD (week 24) | Yes | Daily | <0.01 (<.01–.14) | 0.15 (.08–.29) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 2880 mg + 960 mg QW (week 21) | Yes | Weekly | <0.01 (<.01–.15) | 0.13 (.06–.28) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 2880 mg + 960 mg QW (week 24) | Yes | Weekly | <0.01 (<.01–.14) | 0.17 (.09–.30) | 0.05 (.03–.09) | 0.04 (.02–.07) |
| 2880 mg Q4W | No | Monthly | <0.01 (<.01–.13) | 0.26 (.19–.35) | 0.06 (.03–.11) | 0.04 (.02–.08) |
| 160 mg QD | No | Daily | <0.01 (<.01–.15) | 0.12 (.05–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 320 mg QD | No | Daily | <0.01 (<.01–.15) | 0.12 (.05–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 960 mg QW | No | Weekly | <0.01 (<.01–.14) | 0.14 (.07–.28) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| High-risk woman with high clearance (95% percentile of clearance distribution) | ||||||
| 2880 mg + 160 mg QD (day 3) | Yes | Daily | <0.01 (<.01–.15) | 0.12 (.05–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 2880 mg + 160 mg QD (week 24) | Yes | Daily | <0.01 (<.01–.14) | 0.16 (.08–.29) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 2880 mg + 960 mg QW (week 21) | Yes | Weekly | 0.03 (<.01–.13) | 0.33 (.28–.40) | 0.07 (.04–.13) | 0.05 (.02–.09) |
| 2880 mg + 960 mg QW (week 24) | Yes | Weekly | 0.04 (<.01–.13) | 0.35 (.29–.41) | 0.08 (.04–.13) | 0.05 (.03–.10) |
| 2880 mg Q4W | No | Monthly | 0.07 (.02–.13) | 0.39 (.33–.45) | 0.11 (.07–.18) | 0.08 (.04–.14) |
| 160 mg QD | No | Daily | <0.01 (<.01–.15) | 0.13 (.06–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 320 mg QD | No | Daily | <0.01 (<.01–.15) | 0.13 (.05–.27) | 0.05 (.03–.09) | 0.03 (.02–.07) |
| 960 mg QW | No | Weekly | 0.03 (<.01–.13) | 0.34 (.28–.40) | 0.07 (.04–.13) | 0.05 (.02–.10) |
Data are presented as probability (95% confidence intervals).
Abbreviations: LAMP, loop-mediated isothermal amplification; PQ, piperaquine; Q4W, every 4 weeks; QD, once daily; QW, once weekly.