Table 1.
Baseline Characteristics of the Adult Population of the South-East Asian Quinine Artesunate Malaria Trial Dataset
| Variable | Whole Sample | Discharged | Died | P Value |
|---|---|---|---|---|
| Demographics | ||||
| Country (total n) | 1217 | 976 | 241 | <.001 |
| Myanmar n (%) | 466 (38.3) | 395 (40.5) | 71 (29.5) | |
| Bangladesh n (%) | 418 (34.4) | 302 (30.9) | 116 (48.1) | |
| India n (%) | 137 (11.3) | 105 (10.8) | 32 (13.3) | |
| Indonesia n (%) | 196 (16.1) | 174 (17.8) | 22 (9.1) | |
| Age in years (total n) | 1217 | 976 | 241 | <.001 |
| Median and IQR | 28 (21;40) | 27 (21;38) | 30 (23;45) | |
| Gender (total n) | 1217 | 976 | 241 | .835 |
| Females (reference) n (%) | 292 (24.0) | 234 (24.0) | 58 (24.1) | |
| Males n (%) | 925 (76.0) | 742 (76.0) | 183 (75.9) | |
| Clinical factors on admission | ||||
| Systolic blood pressure in mmHg (total n) | 1207 | 971 | 236 | .224 |
| Median and IQR | 100 (90;120) | 100 (90;120) | 110 (92;120) | |
| Respiratory rate in breaths/minute (total n) | 1215 | 975 | 240 | <.001 |
| Median and IQR | 24 (20;32) | 24 (20;32) | 28 (22;36) | |
| Temperature in C (total n) | 1215 | 975 | 240 | .023 |
| Mean and SD | 38.05 (1.18) | 38.09 (1.19) | 37.90 (1.12) | |
| Glasgow Coma Scale score (total n) | 1217 | 976 | 241 | <.001 |
| Median and IQR | 12 (9;15) | 13 (9.5;15) | 8 (6;11) | |
| Seizures (total n) | 1217 | 976 | 241 | .258 |
| Seizures present n (%) | 114 (9.4) | 85 (8.7) | 29 (12.0) | |
| Laboratory results on admission | ||||
| Blood urea nitrogen mg/dL (total n) | 1157 | 933 | 224 | <.001 |
| Median and IQR | 30 (17;60) | 35 (15;45) | 71 (37.5;107.5) | |
| Base-excess mmol/L (total n) | 1103 | 890 | 213 | <.001 |
| Mean and SD | -4.49 (6.95) | -2.83 (5.53) | -11.42 (7.93) | |
| Log parasite count (total n) | 1153 | 921 | 232 | <.001 |
| Mean and SD | 10.56 (2.41) | 10.37 (2.38) | 11.31 (2.38) | |
| Haemoglobin mg/dL(total n) | 1142 | 920 | 222 | .631 |
| Mean and SD | 10.19 (3.31) | 10.21 (3.33) | 10.09 (3.24) | |
| Clinical conditions developed during admission | ||||
| Shock noted (total n) | 1217 | 976 | 241 | <.001 |
| Shock developed n (%) | 54 (4.4) | 11 (1.1) | 43 (17.8) | |
| Coma noted (total n) | 1217 | 976 | 241 | <.001 |
| Coma developed n (%) | 103 (8.5) | 43 (4.4) | 60 (24.9) | |
| Seizures noted (total n) | 1217 | 976 | 241 | <.001 |
| Seizures developed n (%) | 58 (4.7) | 23 (2.4) | 35 (14.5) | |
| Sepsis noted (total n) | 1217 | 976 | 241 | <.001 |
| Sepsis developed n (%) | 85 (7.0) | 49 (5.0) | 36 (14.9) | |
| Anaemia noted (total n) | 1217 | 976 | 241 | .911 |
| Anaemia developed n (%) | 29 (2.4) | 23 (2.4) | 6 (2.5) | |
| Treatment | ||||
| Previous effective antimalarials (total n) | 1217 | 976 | 241 | .675 |
| Previous treatment given n (%) | 216 (17.8) | 171 (17.5) | 45 (18.7) | |
| Study treatment (total n) | 1217 | 976 | 241 | .001 |
| Quinine (reference) n (%) | 607 (49.9) | 460 (47.1) | 147 (61.0) | |
| Artesunate n (%) | 610 (50.1) | 516 (52.9) | 94 (39.0) | |
The bold values are those that are significant results (ie, P < .05).
Abbreviations: IQR, inter-quartile range; SD, standard deviation.