Table 2.
Pharmacokinetic Parameters for Primaquine and Carboxyprimaquine in Venous Plasma and Breast Milk
| Parameter | Primaquine | Carboxyprimaquine | ||
|---|---|---|---|---|
| Day 0 | Day 13 | Day 0 | Day 13 | |
| Venous plasma | ||||
| Tmax, h | 2.00 (0.983–4.02) | 2.99 (1.05–4.00) | 12.0 (6.00–18.00) | 6.04 (3.00–17.6) |
| Cmax, ng/mL | 139 (66.1–215) | 132 (75.1–196) | 833 (486–1280) | 1370 (783–2250) |
| AUCT, h × ng/mL | 1220 (499–2360) | 1090 (460–2330) | 16300 (9570–24800) | 26900 (15300–45800) |
| AUC∞, h × ng/mL | 1310 (529–3030) | 1170 (475–2880) | ||
| CL/F, L/h | 23.5 (14.8–60.1) | 25.8 (9.64–97.7) | ||
| V/F, L | 226 (102–458) | 191 (117–625) | ||
| Breast milk | ||||
| Tmax, h | 3.42 (1.03–7.90) | 3.87 (1.03–6.83) | 19.4 (4.72–23.7) | 4.17 (1.02–23.6) |
| Cmax, ng/mL | 44.0 (31.4–99.0) | 43.9 (26.8–116) | 7.15 (3.98–19.4) | 12.1 (7.02–28.4) |
| AUCT, h × ng/mL | 420 (179–1150) | 376 (164–1170) | 100 (6.17–236) | 159 (52.2–480) |
Data are presented as median (range).
Abbreviations: AUC∞, area under the curve extrapolated to infinity; AUCT, area under the curve until last observation; CL/F, oral elimination clearance; Cmax, maximum concentration; Tmax, time to maximum concentration; V/F, apparent oral volume of distribution.