Table 3.

Primaquine Pharmacokinetic Parameters Specific to Infant Feeding

Parameter	Day 0	Day 13
Maternal dose, mg/kg	0.50	0.50
Total daily infant dose, µg/kga	1.62 (0.46–3.63)	1.17 (0.08–3.42)
Total daily infant dose, µg/kgb	2.98 (1.15–9.10)	2.58 (1.06–8.22)
Milk-plasma ratio, AUCmilk/AUCven	0.34 (0.12–0.64)	0.37 (0.24–0.61)
Relative infant dose, %c	0.618 (0.231–1.82)	0.517 (0.212–1.64)

Data are presented as median (range).

Abbreviations: AUC_milk, area under the time-concentration curve until the last observation for breastmilk; AUC_ven, area under the time-concentration curve until the last observation for venous plasma.

^aTotal daily dose per kilogram body weight of the baby, based on Equation 1 in Methods.

^bTotal daily dose per kilogram body weight of the baby, based on Equation 2 in Methods.

^cCalculated based on Equations 2 and 3 in Methods.