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. 2018 Sep 13;8:13741. doi: 10.1038/s41598-018-32205-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Suppression of cell growth by PI polyamide treatment (56-1 or 56-2) in primary AML cells. (a–d) Two primary AML cell samples with high expression of EVI1 and GPR56 (a,b) and two AML cell samples with low expression of EVI1 and GPR56 (c,d) were not treated (P) or treated with 1 μM PIP/AP2 (AP2), PIP/56-1 (56-1), or PIP/56-2 (56-2) or solvent only (C) and analyzed for cell growth by Trypan blue exclusion. Data represent the mean ± S.D. of triplicate determinations. **P < 0.01 between parental control and others (Student’s t-test). Data are representative of three independent experiments. (e) Colony formation assays were performed on human CD34⁺ progenitor cells not treated or treated with various PIPs (AP2, 56-1, or 56-2) or DMSO only (C). Data represent the mean ± S.D. of triplicate determinations. Data are representative of three independent experiments.