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. 2018 Sep 13;50(9):122. doi: 10.1038/s12276-018-0147-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The IPGTT of experimental mice and the glucose area under the curve (AUC) during the IPGTT. b The ITT and the glucose inverse AUC during the ITT. c Body weight measurement and d daily energy intake in mice (5 animals/treatment group). Closed circles, ND; opened circles, HFD; closed triangles, HFD + METRNL. Means ± SEM were calculated from five separate animals. ^***P < 0.001 and ^**P < 0.01 compared to ND treatment.^!!!P < 0.001,^!!P < 0.01 and ^!P < 0.05 compared to HFD treatment