Table 2.

Binding free energy components for the active CB1-ligand complexes determined by using the MM/PBSA method.

Ligand	ΔEMM	ΔEvdW	ΔEelec	ΔEpolar	ΔEnonpolar	ΔEsolv	ΔEbind
THC	−56.76	−52.83	−3.93	15.28	11.43	26.71	−30.05
THCV	−53.49	−42.87	−10.62	10.20	15.26	25.46	−28.03
Taranabant	−73.45	−59.47	−13.98	26.96	15.19	42.15	−31.30