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. 2018 Sep 7;9:2037. doi: 10.3389/fimmu.2018.02037

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Copyright © 2018 Curtale, Renzi, Mirolo, Drufuca, Albanese, De Luca, Rossato, Bazzoni and Locati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammatory genes are enriched in miR-125a~99b~let-7e cluster predicted target genes. (A) Absolute number and percentage of miR-125a-5p, let-7e-5p, and miR-99b-5p predicted target genes included in the Immune system process genonthology category (GO term 0002376) and in the relative subcategories Immune response (dark gray), Antigen processing and presentation (light gray), and Macrophage activation (blue). (B) Molecular and cellular functions significantly enriched in predicted target genes of miR-125a-5p (green), let-7e-5p (red), and miR-99b-5p (brown) as identified by the IPA analysis. The number of molecules involved and the p value calculated with the right-tailed Fisher's exact test are reported in the color code corresponding to each miR.