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. 1999 Jul-Aug;6(4):313–321. doi: 10.1136/jamia.1999.00660313

Table 6.

Non-missed-dose Medication Errors, By Type and Period

Baseline (n = 10,070) Period 1 (n = 15,025) Period 2 (n = 13,139) Period 3 (n = 14,352) P* Value
Dose errors 81 (47.5) 90 (34.3) 114 (63.9) 40 (21.3) 0.03
Frequency errors 43 (25.2) 4 (1.5) 2 (1.1) 4 (2.1) 0.0001
Route errors 25 (14.7) 5 (1.9) 6 (3.3) 4 (2.1) 0.0001
Substitution errors 12 (7.0) 3 (1.1) 3 (1.7) 0 (0) 0.0001
Documented allergy 10 (5.9) 1 (0.4) 1 (0.6) 0 (0) 0.0001
Inappropriate drug 7 (4.1) 3 (1.1) 1 (0.6) 0 (0) 0.002
Avoidable delay 7 (4.1) 0 (0) 0 (0) 0 (0) 0.003
Drug-drug interaction 2 (1.2) 0 (0) 1 (0.6) 0 (0) 0.19
Inadequate follow-up 1 (0.6) 0 (0) 0 (0) 0 (0) 0.17
Other 54 (31.7)
28 (10.7)
4 (2.2)
2 (1.1)
0.0001
Total
242 (142.0)
134 (51.2)
132 (74.0)
50 (26.6)
0.0001
Note: The number of occurrences of each error is shown, followed by the rate per 1,000 patient-days in parentheses.
*

The P value was determined by the chi-squared test for trend across the four periods.

Of these errors, 77 of 90 (86 percent) in period 1 and 101 of 114 (89 percent) in period 2 were potassium chloride errors, whereas none of the 40 dose errors in period 3 was a potassium chloride error.