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. 2018 Sep 14;38(5):BSR20180678. doi: 10.1042/BSR20180678

Figure 6. MiR-29s affect the H3K9 methylation status in NSCLC.

Figure 6

(A) TP53 and Suv39h1 mRNA levels after transfection of miR-29s mimics or Scr NC into A549 and PC14 cells. (B) TP53 and Suv39h1 mRNA levels after transfection of miR-29s inhibitors or Scr NC into BEAS-2B cells. Histone H3K9 methylation status in (C) NSCLC cells (A549 and PC14) with overexpressed miR-29s and (D) BEAS-2B cells with downexpressed miR-29s were examined by Western blot using antibodies specific for H3K9me2 and H3K9me3 (di- and trimethylation of H3K9, respectively); expression levels of histone H3 protein were used as an internal control. (E) Schematic illustration of the proposed TP53/miR-29s/SETDB1 regulatory circuitry in NSCLC. **P<0.01; ***P<0.001