Table 7.
Allogeneic-HSCT | |||||
---|---|---|---|---|---|
Variables | sjTREC/μg DNA (median: 166.36) |
||||
<median | ≥median | p | |||
n(%)/n(%)/n(%) | n(%)/n(%)/n(%) | ||||
Age groups | <50/≥50 years old | 17 (77.3)/5 (22.7) | 26 (89.7)/3 (10.3) | 0.268 | |
Sex | Male/female | 11 (50)/11 (50) | 12 (41.4)/17 (58.6) | 0.540 | |
Diagnosis | ALL/AML/MDS | 9 (40.9)/12 (54.5)/1 (4.5) | 12 (41.4)/15 (51.7)/2 (6.9) | 0.932 | |
Treatment for a prior disease | Chemo/chemo plus radio | 21 (95.5)/1 (4.5) | 28 (96.6)/1 (3.4) | 0.999 | |
Bone marrow status before HSCT | MRD/activea/CR | 7 (31.8)/1 (4.5)/14 (63.6) | 6 (20.7)/2 (6.9)/21 (72.4) | 0.650 | |
Time between last chemo/radio and HSCT | ≥6 months/<6 months | 4 (18.2)/18 (81.8) | 5 (17.2)/24 (82.8) | 0.999 | |
Conditioning regimen | MAC/RIC | 12 (54.5)/10 (45.5) | 23 (79.3)/6 (20.7) | 0.059 | |
Stem cell source | PBSC/BMSC | 10 (45.5)/12 (54.5) | 11 (37.9)/18 (62.1) | 0.589 | |
Acute-GvHD | Absent/present | 10 (45.5)/12 (54.5) | 12 (41.4)/17 (58.6) | 0.771 | |
Chronic-GvHD | Absent/present | 9 (40.9)/13 (59.1) | 15 (51.7)/14 (48.3) | 0.443 | |
Bacterial infection episodes | Not present/present | 7 (31.8)/15 (68.2) | 8 (27.6)/21 (72.4) | 0.743 | |
CMV infection episodes | Not present/present | 1 (4.5)/21 (95.5) | 9 (31)/20 (69) | 0.030 | |
Fungal infection episodes | Not present/present | 21 (99.5)/1 (4.5) | 25 (86.2)/4 (13.8) | 0.375 | |
Clinical status | Dead/alive | 4 (18.2)/18 (81.8) | 2 (6.9)/27 (93.1) | 0.383 | |
Total | 51 (100%) | 22 (100) | 29 (100) | Not applied |
ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; chemo, chemotherapy; BMSC, bone marrow stem cell; CMV, cytomegalovirus; CR, complete response; GvHD, graft-versus-host disease; HD, Hodgkin’s disease; HSCT, hematological stem cell transplantation; MAC, myeloablative conditioning; MDS, myelodysplastic syndrome; MRD, minimal residual disease; MM, multiple myeloma; PBSC, peripheral blood stem cell; PR, partial response; radio, radiotherapy; RIC, reduced intensity conditioning; sjTREC, signal joint TREC.
aActive: three cases of MDS have not received any treatment before HSCT.