Table 1.
Summary of Evolutionary Analysis of “Established” Lineages of DENV-1 Genotype III
| DENV-1 Strains | Genome-wide Genetic Signature (Non-synonymous) | Mean Evolutionary Ratea (95% HPD) | tMRCAb (95% HPD) | Closest Ancestor (Posterior Probability) |
|---|---|---|---|---|
| GIII 2011 | prM-I120M + E-I129T + E-F337I + NS1-D278N | 7.3 (2.8–12.7) | 5.6 (5.2–6.1) | India 2009 (0.997) |
| GIII 2012 | prM-I120M + E-I129T + E-S449N + NS2A-S142P | 8.1 (3.9–14.0) | 4.9 (4.4–5.4) | India 2009 (0.997) |
| GIII 2013 | E-F337I + NS1-D278N | 5.5 (2.8–8.5) | 5.9 (5.0–6.9) | India 2009 (0.976) |
GIII, genotype III; HPD, highest posterior density; tMRCA, time to most recent common ancestor.
a
Expressed in ×10−4 nucleotide substitutions/site/year.
b
Expressed in years, to be calculated from 2016.