Table 2.
Summary of Evolutionary Analysis of “Established” Lineages of DENV-1 Genotype I
| DENV-1 Strains | Genome-wide Genetic Signature (Non-synonymous) | Mean Evolutionary Ratea (95% HPD) | tMRCAb (95% HPD) | Closest Ancestor (Posterior Probability) |
|---|---|---|---|---|
| GIa | NS1-F323Y + NS2A-M168I + NS5-I114V + NS5-V231I + NS5-N285C + NS5-P525S + NS5-D554E + NS5-L562Q | 6.8 (4.6–9.6) | 6.8 (5.5–8.3) | Singapore 2005 (0.998) |
| GIb | preM-V135A + E-S338L + E-T359S + NS2B-L21F + NS4A-V68M + NS5-P137H + NS5-I181V + NS5-V413I + NS5-P525S | 8.0 (3.8–13.2) | 2.5 (2.2–2.8) | China 2011 (0.998) |
| GIc | NS2B-I106 + NS5-V413I | 7.7 (3.8–12.3) | 3.7 (3.1–4.4) | Singapore 2013 (0.998) |
GI, genotype I; HPD, highest posterior density; tMRCA, time to most recent common ancestor.
a
Expressed in ×10−4 nucleotide substitutions/site/year.
b
Expressed in years, to be calculated from 2016.