Table 1.
Shared biological pathways between AD and IS.
| Pathway ID | Pathway name | AD |
IS |
Pcombined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | O | E | R | P-value | C | O | E | R | P-value | |||
| KEGG | ||||||||||||
| hsa05214 | Glioma | 66 | 11 | 5.19 | 2.12 | 1.82E-02 | 66 | 8 | 3.38 | 2.37 | 3.62E-03 | 6.59E-05 |
| hsa04620 | Toll-like receptor signaling pathway | 106 | 14 | 8.33 | 1.68 | 1.09E-02 | 106 | 10 | 5.42 | 1.84 | 7.15E-03 | 7.79E-05 |
| hsa05223 | Non-small cell lung cancer | 56 | 10 | 4.4 | 2.27 | 1.30E-02 | 56 | 8 | 2.86 | 2.79 | 1.86E-02 | 2.42E-04 |
| hsa04650 | Natural killer cell mediated cytotoxicity | 135 | 18 | 10.61 | 1.7 | 8.60E-03 | 135 | 15 | 6.91 | 2.17 | 3.25E-02 | 2.80E-04 |
| hsa04072 | Phospholipase D signaling pathway | 144 | 20 | 11.32 | 1.77 | 3.68E-02 | 144 | 13 | 7.37 | 1.76 | 3.57E-02 | 1.31E-03 |
| hsa05161 | Hepatitis B | 146 | 18 | 11.48 | 1.57 | 3.72E-02 | 146 | 13 | 7.47 | 1.74 | 4.40E-02 | 1.64E-03 |
| PANTHER | ||||||||||||
| P00012 | Cadherin signaling pathway | 153 | 24 | 13.30 | 1.80 | 2.46E-03 | 153 | 21 | 8.94 | 2.35 | 1.32E-04 | 3.25E-07 |
| P00057 | Wnt signaling pathway | 294 | 35 | 25.57 | 1.37 | 2.71E-02 | 294 | 30 | 17.17 | 1.75 | 1.07E-03 | 2.90E-05 |
| REACTOME | ||||||||||||
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 132 | 20 | 10.23 | 1.96 | 2.79E-03 | 132 | 14 | 6.54 | 2.14 | 5.75E-03 | 1.60E-05 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 49 | 8 | 3.8 | 2.11 | 3.32E-02 | 49 | 8 | 2.43 | 3.29 | 2.58E-03 | 8.57E-05 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 43 | 8 | 3.33 | 2.4 | 1.60E-02 | 43 | 6 | 2.13 | 2.81 | 1.85E-02 | 2.96E-04 |
| R-HSA-1483255 | PI metabolism | 78 | 11 | 6.04 | 1.82 | 3.72E-02 | 78 | 9 | 3.87 | 2.33 | 1.47E-02 | 5.47E-04 |
| WIKIPATHWAYS | ||||||||||||
| WP2261 | Signaling pathways in glioblastoma | 83 | 12 | 6.81 | 1.76 | 3.68E-02 | 83 | 10 | 4.65 | 2.15 | 1.67E-02 | 6.15E-04 |
C, the number of reference genes in the category; O, the number of genes in the list of disease-related genes of interest and also in the category; E, the expected number in a category; R, the ratio of enrichment. The threshold of statistical significance for a pathway associated with AD and IS was P < 0.05.