Figure 2.

Two-Dimensional Measurements of Patient Crista Architecture Reveal Increased Width and Blunted Apex Curvature, Related to Figures S2–S4 and Videos S1, S2, S3, and S4

(A) Representative two-dimensional slices through cryoelectron tomograms, outlining cristae (white) for two-dimensional measurement of crista lumen width at base, middle, and tip (inset; blue) and of crista apex angle (inset; red); scale bars represent 200 nm.

(B) Quantitation of crista lumen width in Å for control (n = 41 cristae) and patient (n = 24 cristae); ^∗ indicates p < 0.0001.

(C) Quantitation of crista apex angle for control (n = 37 cristae) and patient (n = 12 cristae). Black bars denote averages. For all graphs, significance was assessed by the Mann-Whitney test at 95% confidence. Data were collected from at least three independent cells grown on three independent grids for both patient and control; * indicates p < 0.0001.

* indicates statistical significance.