Figure 6.

AMF-Controlled Spatiotemporal Drug Release from an LM-Hydrogel Microdevice

(A) Schematic illustration of gel-sol transition of LM-agarose gel composite upon AMF induction.

(B) 1 mL hydrogel matrix (agarose, 2% w w⁻¹; RhB, 0.5 mg mL⁻¹) containing LM (20 μL) in addition with 2 mL water before and after AMF (200 A m⁻¹, 245 kHz) exposure for 3 min.

(C and D) AMF-modulated release profile (C) and temperature change (D) of LM- or PBS-containing hydrogel matrix over the period of time. The “ON” stage indicates exposure to the AMF (200 A m⁻¹, 245 kHz), whereas the “OFF” stage indicates absence of the AMF.

(E) Depiction of the LM/RhB-Gel microdevice consisting of LM (20 μL), agarose (2%, w w⁻¹, 200 μL), RhB (0.5 mg mL⁻¹), and a PCR tube.

(F) Sequential snapshots of LM/RhB-Gel microdevice electromagnetic levitation induced by low-powered AMF (100 A m⁻¹, 245 kHz).

(G) Photograph of the LM/RhB-Gel microdevice electromagnetic levitation and RhB release behavior induced by high-powered AMF (200 A m⁻¹, 245 kHz).