Figure 6.

Coupling of V1 neurons’ firing to population activity is negatively correlated with visual responsiveness and orientation selectivity. (A) Schematic representation of coupling strength calculation. Across AM visual response testing, spike times for individual neurons (indicated by arrows) were cross-correlated with population activity from all other simultaneously recorded neurons (i.e., with the reference neuron’s activity subtracted from total firing; shown in bottom raster). (B) Superimposed cross-correlogram (CCGs) of spiking from the neurons indicated with arrows in the raster plot are shown, following subtraction of the shift-predictor described in “Materials and Methods” section. Coupling strength for each neuron was calculated as the value of the cross-correlation at 0 lag time. (C) For baseline (AM) data aggregated from the four experimental groups, coupling strength and spontaneous firing rate show a strong positive correlation. In contrast, at baseline, coupling strength is negatively correlated with both RI (D) and OSI45 (E). Spearman rank order R- and p-values shown.