Figure 1.

Alkyl-Heck-Type Reaction of Alkenes

Top: One-pot process from aliphatic acid: First, 2-ethylhexanoic acid 1 (1.5 mmol), TBHP (1.5 mmol), and TFAA (2.0 mmol) at 0°C–rt for 4 hr, and then THF (2 mL), alkene (0.5 mmol), and HOTf (0.05 mmol) were added. The mixture was stirred at 50°C for 8 hr; yields of isolated products.

Bottom: HOTf (0.35 mmol) was added for 16, 18, 19, and 21.

The acetyl group on oxygen atom was removed under the reaction conditions for 19.

HOTf (0.75 mmol) was added for 22.

See also Figures S45–S94.