. 2018 Jul 25;9(35):7053–7057. doi: 10.1039/c8sc02513d

Table 1. Cu²⁺-nitrile-mediated activation of A′3P and effect of Gly or GlyGly.


Entry	Nitrile	R	Yield of 3 or 2′-transfer adducts ^a (%)
			CuCl₂		CuCl₂ and Gly		CuCl₂ and GlyGly
			3 ^b	2′-adduct	3 ^b	2′-adduct	3 ^b	2′-adduct
1	1		84	n.d. ^c	85 ^d	n.d.	80	n.d.
2	4		n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
3	5		n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
4	6		5	n.d.	2	n.d.	n.d.	n.d.
5	7		24	15	21	8	23	5.4
6	8		53	6	50	4	97 ^e	3
7	10		75	n.d.	60	n.d.	5	n.d.
8	11		35	n.d.	22	n.d.	34	n.d.

^aStandard reaction conditions: nitrile (100 mM), 2 (50 mM), CuCl₂ (25 mM) and Gly or GlyGly (50 mM) in 90% H₂O, 10% D₂O at pH 4 (entries 1, 5 and 8) or pH 5.5 (entries 2, 3, 4, 6 and 7), heated at 40 °C for 20 hours.

^bInferred from the amount of 3 plus adenosine 2′-phosphate A2′P 12, assuming that when 3 hydrolyses it always gives 2 and 12 in 1.8 : 1 ratios.17

^cNot detected.

^dInitial pH 5.5.

^eInitial pH 4.

Table 1. Cu2+-nitrile-mediated activation of A′3P and effect of Gly or GlyGly.

Table 1. Cu²⁺-nitrile-mediated activation of A′3P and effect of Gly or GlyGly.