Figure 4.

Canonical pathways dysregulated in lungs of SE2^−/− mice. Genome-wide transcriptomic analysis was performed on 2-mo-old SE2^−/− mice by using Affymetrix microarrays. To estimate biologic mechanisms that are altered in lungs of SE2^−/− mice, we performed pathways analysis for genes identified as differentially expressed. Shown here are significantly (P < 0.05) affected canonical pathways, in which the x axis represents the frequency (percentage) of genes within each canonical pathway for the entire genome (gray) or those differentially expressed in lungs of SE2^−/− mice (black). CTLA, cytotoxic T-lymphocyte–associated protein; iCOS, inducible T-cell costimulator; iCOSL, inducible T-cell costimulor ligand; NFAT, nuclear factor of activated T cells.