Figure 5.

Increased mRNA levels of numerous proinflammatory molecules in lungs of young SE2^−/− mice. We studied the expression of inflammatory chemokines, cytokines, and adhesion molecules in 2-mo-old SE2^−/− (KO) and CTL mouse lung tissue at the RNA (A–D) level. A) Expression of adhesion molecules. B) Expression of genes involved in the development of ectopic lymphoid structures. C) Expression of chemokines responsible for recruitment of inflammatory cells. D) Expression of cytokines produced by immune cells at inflammatory sites (n ≥ 5). Data are presented as means ± sem. ^#P < 0.05; ^##P < 0.09 by Mann–Whitney U test.