TABLE 3.
Associations of ENTPD1 htSNPs with VTE in discovery and replication groups
| SNP | VTE [n (%)] | Control [n (%)] | Genetic model |
|
|---|---|---|---|---|
| Additive | Dominant | |||
| Discovery cohort | ||||
| rs3176891 | ||||
| AA | 24 (0.22) | 33 (0.31) | OR 1.87 | OR 1.73 |
| AG | 47 (0.44) | 62 (0.57) | CI 1.08–3.25 | CI 0.75–3.98 |
| GG | 37 (0.34) | 13 (0.12) | P = 0.025* | P = 0.195 |
| rs61731067 | ||||
| GG | 95 (0.91) | 98 (0.91) | OR 0.932 | OR 0.96 |
| GC | 8 (0.08) | 10 (0.09) | CI 0.36–2.42 | CI 0.35–2.60 |
| CC | 1 (0.01) | 0 | P = 0.884 | P = 0.93 |
| rs3176886 | ||||
| AA | 84 (0.78) | 82 (0.76) | OR 1.26 | OR 1.16 |
| AG | 20 (0.19) | 20 (0.18) | CI 0.71–2.25 | CI 0.60–2.27 |
| GG | 3 (0.03) | 6 (0.06) | P = 0.43 | P = 0.65 |
| rs11188504 | ||||
| AA | 56 (0.53) | 40 (0.37) | OR 1.32 | OR 1.87 |
| AC | 40 (0.37) | 60 (0.56) | CI 0.77–2.28 | CI 1.08–3.22 |
| CC | 11 (0.10) | 8 (0.07) | P = 0.31 | P = 0.12 |
| rs3181123 | ||||
| CC | 51 (0.47) | 60 (0.56) | OR 1.31 | OR 1.20 |
| CT | 48 (0.45) | 41 (0.38) | CI 0.74–2.32 | CI 0.60–2.39 |
| TT | 9 (0.08) | 7 (0.06) | P = 0.35 | P = 0.60 |
| rs10748643 | ||||
| AA | 21 (0.20) | 30 (0.28) | OR 1.83 | OR 1.96 |
| AG | 41 (0.38) | 53 (0.50) | CI 1.1–3.06 | CI 0.82–4.69 |
| GG | 45 (0.42) | 24 (0.22) | P = 0.020* | P = 0.13 |
| Replication study (Seattle HVH study) | ||||
| rs3176891 | ||||
| AA | 178 (0.22) | 330 (0.28) | OR 1.08 | OR 1.261 |
| AG | 417 (0.52) | 552 (0.46) | CI 0.94–1.24 | CI 1.01–1.59 |
| GG | 205 (0.26) | 315 (0.26) | P = 0.26 | P = 0.044* |
Where numbers do not equal 108 in discovery group, few genotypes could not be determined. OR expressed as 95% CI. Analyses in discovery cohort were for entire group (all races). SNP appear in downward order based on 5′ to 3′ location, except for rs10748643. Primary analyses were additive genetic models. Data for secondary outcomes in discovery and replication studies are in Supplemental Tables S2, S3, and S4. All P values for discovery group reflect adjustment for multiple hypotheses (except for rs10748643, which was not htSNP), age, sex, and race. *Statistically significant, P < 0.05.