Table 1. Study, Patient and Treatment Characteristics.
| Characteristic | Study Name | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| COAST34 | JCEP23 | LEO35 | OPUS36 | OTP37 | PIANO18 | RAISE-ETP9 | STEP19 | Valencia 12 Months20 | Valencia 6 Months22 | |
| Study Characteristics | ||||||||||
| Duration, mo | 9 | 24 | 18 | 24 | 24 | 9 | 24 | 12 | 12 | 6 |
| No. of sites, location | 1, South London/UK | 1, Hong Kong | 1, London/UK | 5, Denmark | 1, Norway | 117, Italy | 34, US | 1, US | 1, Mexico | 1, Mexico |
| No. at baseline (EIS/TAU) | 59 (32/27) |
200 (100/100) |
144 (71/73) |
547 (275/272) |
50 (30/20) |
444 (272/172) |
404 (223/181) |
117 (60/57) |
88 (44/44) |
120 (60/60) |
| Inclusion criteria | 1st Episode of any functional psychosis in past 5 y of contact | FEP according to DSM IV | ≤2 Episodes of nonaffective PSY; SCZ; SzT; DEL | 1st Episode SCZ spectrum d/o including DEL and SzT; ≤12 wk AP medication | Recent-onset SCZ (≤2 y since FEP), with more than 1 acute episode | 1st Lifetime contact with the center for any functional PSY | FEP (SCZ-spectrum disorder; psychosis NOS, brief psychosis), ≤6 mo AP medication | FEP (nonaffective); ≤5 y ago; ≤12 wk AP medication | FEP (SCZ); stable after first AP medication (≥15 d); no substance abuse | FEP (SCZ); stable after first AP medication (≥15 d); no substance abuse |
| Early intervention services components | Medication review; vocational/ educational counseling; CBT; family PE/counseling; family therapy; crisis response team/crisis management | Medication review; vocational/ educational counseling; CBT; family PE/counseling; crisis response team/crisis management; SST | Medication review; vocational/ educational counseling; CBT; family PE/counseling | Medication review; family PE/counseling; family therapy; crisis response team/crisis management; SST | Medication review; CBT; family PE/counseling; family therapy; crisis response team/crisis management; SST | Medication review; CBT; family PE/counseling; family therapy | Medication review; vocational/ educational counseling; CBT; family PE/counseling | Medication review; vocational/ educational counseling; CBT; family PE/counseling; family therapy | Medication review; family PE/counseling; family therapy; SST | Medication review; family PE/counseling; family therapy; SST |
| Patient Characteristics | ||||||||||
| Age, mean (SD) [range] | 28 (8) [8-65] |
36.6 (8.7) [26-55] |
26.3 (6.2) [16-40] |
26.6 (6.4) [18-45] |
25.4 (4.6) [18-35] |
30.2 (9.6) [18-54] |
23.1 (5.1) [16-45] |
22.5 (4.9) [16-45] |
24.3 (3.1) [16-50] |
26.8 (5.0) [16-50] |
| Male, % | 75 | 43 | 65 | 59 | 62 | 59 | 73 | 98 | 75 | 66 |
| Illness Characteristics | ||||||||||
| Diagnosis, % | SCZ/SzA: 83.1; BP: 12.5; substance-induced PSY: 1.0 | SCZ: 44.0; SzF: 17.0; brief PSY: 12.0; PSY NOS: 6.0; SzA: 1.0 | SCZ: 69.4 | SCZ: 66.2; SzT: 14.4; brief PSY: 8.2; SzA: 4.6; DEL: 4.6; PSY NOS: 2.0 | SCZ: 80; SzA: 12; SzF: 8 | SCZ: 27; brief PSY: 18; DEL: 16; mania with PSY: 13; MDD with PSY: 9; SzA: 9; PSY NOS: 6; SzT: 2 | SCZ: 52.9; SzF: 16.6; SzA DEP: 14.1; PSY NOS: 9.9; SzA BP: 5.9; brief PSY: 0.5 | SCZ/SzA: 29.0 | SCZ: 100.0 | SCZ: 100.0 |
| DUP, mean (median), wk | NR | 73.6 (13.3) | 9.1 (16.0) | NR | NR | 45.2 (8.0) | 193.5 (74.0) | 43.9 (12.0) | NR | NR |
Abbreviations: AP, antipsychotic; BP, bipolar; CBT, cognitive behavioral therapy; COAST, Croydon Outreach and Assertive Support Team; DEL, delusional disorder; DUP, duration of untreated psychosis; EIS, early intervention services; FEP, first episode of psychosis; JCEP, Jockey Club Early Psychosis; LEO, Lambeth Early Onset; MDD, major depressive disorder; NOS, not otherwise specified; NR, not reported; OPUS, specialized assertive intervention; OTP, Optimal Treatment Project; PE, psychoeducation; PIANO, Psychosis: Early Intervention and Assessment of Needs and Outcome; PSY, psychosis; RAISE-ETP, Recovery After an Initial Schizophrenia Episode–Early Treatment Program; SCZ, schizophrenia; SST, social skills training; STEP, Specialized Treatment Early in Psychosis; SzA, schizoaffective; SzA BP, schizoaffective bipolar; SzA DEP, SzA depressive; SzF, schizophreniform disorder; SzT, schizotypal disorder; TAU, treatment as usual.