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. 2018 Apr 9;172(6):525–533. doi: 10.1001/jamapediatrics.2017.5227

Figure 2. White Matter (WM) Structural Connections in Infants With Prenatal Exposure to Selective Serotonin Reuptake Inhibitors (SSRIs).

Figure 2.

A, White matter structural connectomes (90 regions) estimated using diffusion tractography; across both hemispheres, similar connectome organization was evident in each study group: healthy control (HC) infants, SSRI-exposed infants, and prenatal maternal depression (PMD)-exposed infants without SSRI exposure (permutation tests against 1000 randomized connections; P < .05; SSRI, n = 14; PMD, n = 20; HC, n = 58). B, Upper row shows a map of significant group differences in WM connectivity. Regression analyses were conducted on the connectivity matrix using a whole-brain-corrected P < .05 (randomization permutation; false discovery rate control). Lower row shows a representative WM pathway connecting the right amygdala (red) and the right insula (yellow) color-coded by direction. C, Distributions (colored area), quartiles (thick bar), 95% CIs (thin line), and medians (white dots). Open triangles represent infants. The significance of the group differences was based on a regression model performed on the right amygdala-right amygdala connectivity (exhaustive permutations).

aP < .001 compared with the PMD group, P < .001 compared with the HC group, and P = .001 compared with the PMD and HC groups combined.

bP = .80 compared with the HC group.