Table 1. Demographic Data.
| Characteristic | SSRIa (n = 16) |
PMD (n = 21) |
HC (n = 61) |
Test Statistic (df) | P Value |
|---|---|---|---|---|---|
| Age at scan, mean (SD), wk | 4.29 (1.81) | 3.03 (1.65) | 3.30 (1.27) | F2,95 = 3.82 | .02 |
| Gestational age at birth, mean (SD), wk | 38.71 (1.00) | 39.32 (1.04) | 39.43 (1.06) | F2,95 = 3.08 | .05 |
| Sex | χ22 = 0.84 | ||||
| Male | 8 | 8 | 30 | .65 | |
| Female | 8 | 13 | 31 | ||
| Infant birth weight, mean (SD), g | 3754.19 (1320.23) | 4000.57 (755.81) | 3888.78 (746.28) | F2,95 = 0.37 | .69 |
| Maternal age, mean (SD), y | 33.12 (4.20) | 27.55 (6.57) | 31.04 (5.75) | F2,95 = 4.72 | .01 |
| Maternal race/ethnicity | χ26 = 20.91 | ||||
| Hispanic/Latina | 0 | 7 | 19 | .002 | |
| White | 12 | 3 | 16 | ||
| Black/African American | 1 | 8 | 17 | ||
| Other | 3 | 3 | 9 | ||
| Total family income, $ | χ26 = 37.98 | ||||
| 0-25 000 | 1 | 13 | 13 | <.001 | |
| 26 000-50 000 | 1 | 4 | 16 | ||
| 51 000-100 000 | 2 | 2 | 20 | ||
| >100 001 | 12 | 2 | 11 | ||
| Infant SERT genotype | χ26 = 2.66 | ||||
| Long/long | 4 | 8 | 21 | .61 | |
| Short/long | 4 | 7 | 28 | ||
| Short/short | 4 | 2 | 9 | ||
| Depressive disorder | 7b | 16c | |||
| Women with nondepressive disorder | 4d | 3e | 5f | χ22 = 2.91 | .23 |
| Maternal CES-D, prenatal, mean (SD) | 12.63 (12.12) | 24.33 (7.22) | 7.22 (3.99) | F2,95 = 51.80 | <.001 |
| Maternal CES-D, postnatal, mean (SD) | 10.84 (11.44) | 15.8 (9.39) | 6.98 (4.86) | F2,95 = 11.54 | <.001 |
Abbreviations: CES-D, Center For Epidemiologic Studies Depression scale; HC, healthy control; MDD, major depressive disorder; PMD, prenatal maternal depression; SADS, Schedule for Affective Disorders and Schizophrenia; SERT, serotonin transporter; SSRI, selective serotonin reuptake inhibitor.
Exposure to low-level (n = 4), midlevel (n = 7), and high-level (n = 5) SSRI dosage (eMethods in the Supplement) in the first (n = 1), second (n = 2), and third (n = 13) trimesters.
With diagnosis based on SADS score18: major depressive disorder (n = 3) and depressive disorder not otherwise specified (n = 3).
With diagnosis based on SADS score: major depressive disorder (n = 4) and depressive disorder not otherwise specified (n = 12).
With diagnosis based on SADS score: bulimia (n = 1), panic disorder (n = 2), generalized anxiety disorder (n = 1), and obsessive-compulsive disorder (n = 1).
With diagnosis based on SADS score: posttraumatic stress disorder (n = 1), panic disorder (n = 2), agoraphobia (n = 1), obsessive-compulsive disorder (n = 1), and simple phobia (n = 1).
With diagnosis based on SADS score: posttraumatic stress disorder (n = 1) and simple phobia (n = 4).