Figure 2.

Rats exposed prenatally and continuously for 8 wk to unfiltered Beijing air vs. those exposed to filtered Beijing air. A) Biomarkers of oxidative stress, MDA, and 8-isoprostane, in tissues of lung, liver, spleen, and brain of 8-wk-old male pups. *P < 0.05. B) GeneMania network of up-regulated genes involved in cytokine signaling from lung tissue. Black circles indicate query genes identified as up-regulated between groups by RNA-Seq; gray circles, those connected via prediction or expression network analysis. C) Cytokine/chemokine concentrations in epididymal fat tissue of male rats. *P < 0.05, **P < 0.01, ***P < 0.001.