Table 1.
Associations between fatigue severity and impact and demographic features of patients with microscopic colitis.
| Mean fatigue severity score (SD) | p value* | Mean fatigue impact score (SD) | p value* | |
|---|---|---|---|---|
| Type of MC | ||||
| Collagenous colitis | 8.3 (5.0) | 23.1 (27.6) | ||
| Lymphocytic colitis | 7.5 (4.8) | 0.37 | 25.6 (25.0) | 0.61 |
| Sex | ||||
| Female | 8.4 (4.8) | 26.3 (26.8) | ||
| Male | 7.3 (5.0) | 0.26 | 20.8 (25.8) | 0.32 |
| Married or cohabiting | ||||
| Yes | 7.7 (4.6) | 22.0 (23.3) | ||
| No | 8.9 (5.2) | 0.18 | 30.5 (31.1) | 0.08 |
| University graduate | ||||
| Yes | 6.7 (4.3) | 18.2 (17.7) | ||
| No | 8.7 (5.0) | 0.03 | 27.6 (28.8) | 0.07 |
| Current smoker | ||||
| Yes | 11.0 (5.0) | 46.1 (32.3) | ||
| No | 7.8 (4.8) | 0.03 | 22.7 (24.9) | 0.002 |
| Using PPIs | ||||
| Yes | 9.2 (5.1) | 33.6 (29.8) | ||
| No | 7.2 (4.4) | 0.02 | 17.3 (20.5) | <0.001 |
| Using NSAIDs | ||||
| Yes | 7.9 (5.3) | 25.7 (27.4) | ||
| No | 8.3 (4.7) | 0.71 | 24.7 (26.2) | 0.83 |
| Using ranitidine | ||||
| Yes | 9.6 (5.0) | 32.0 (26.1) | ||
| No | 7.9 (4.8) | 0.15 | 23.7 (26.5) | 0.20 |
| Using aspirin | ||||
| Yes | 8.3 (4.8) | 27.0 (24.5) | ||
| No | 8.1 (4.9) | 0.81 | 24.4 (27.3) | 0.63 |
| Using selective serotonin reuptake inhibitors | ||||
| Yes | 9.7 (5.2) | 35.4 (29.0) | ||
| No | 7.8 (4.7) | 0.08 | 22.6 (25.5) | 0.03 |
| Using statins | ||||
| Yes | 8.3 (4.6) | 25.1 (24.1) | ||
| No | 8.1 (5.0) | 0.87 | 25.0 (27.8) | 0.03 |
| Autoimmune thyroid disease | ||||
| Yes | 7 (5.2) | 20.7 (24.1) | ||
| No | 8.4 (4.8) | 0.26 | 25.0 (27.8) | 0.44 |
| Rheumatoid arthritis | ||||
| Yes | 9.8 (5.6) | 36.5 (31.2) | ||
| No | 8.1 (4.8) | 0.34 | 24.3 (26.1) | 0.59 |
| Coeliac disease | ||||
| Yes | 8.0 (5.0) | 29.4 (32.4) | ||
| No | 9.6 (3.5) | 0.33 | 24.7 (26.1) | 0.59 |
| Rome III IBS-type symptoms | ||||
| Present | 10.4 (4.6) | 38.2 (30.4) | ||
| Absent | 7.0 (4.6) | <0.001 | 17.9 (21.2) | <0.001 |
| Stool frequency | ||||
| 1–3 times per day | 6.9 (4.0) | 17.0 (19.6) | ||
| 4–6 times per day | 8.8 (4.7) | 26.3 (26.3) | ||
| 7–9 times per day | 6.3 (4.0) | 17.0 (27.6) | ||
| >10 times per day | 9.6 (6.1) | 0.06 | 38.6 (31.1) | 0.01 |
| Described ongoing symptoms of MC | ||||
| Present | 8.4 (4.6) | 28.6 (27.4) | ||
| Absent | 7.8 (5.2) | 0.52 | 20.7 (25.0) | 0.09 |
| Abnormal anxiety scores | ||||
| Present | 10.8 (4.6) | 42.6 (30.7) | ||
| Absent | 6.5 (4.3) | <0.001 | 14.1 (16.1) | <0.001 |
| Abnormal depression scores | ||||
| Present | 13.8 (3.1) | 61.1 (26.0) | ||
| Absent | 6.7 (4.1) | <0.001 | 15.1 (15.5) | <0.001 |
| High levels of somatization | ||||
| Present | 13.9 (4.3) | 67.3 (26.4) | ||
| Absent | 7.2 (4.3) | <0.001 | 18.2 (19.3) | <0.001 |
*
All comparisons made using student t tests.
IBS, irritable bowel syndrome; MC, microscopic colitis; NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SD, standard deviation.