Generalized additive model of associations between average wall thickness for a hypothetical airway of 10-mm lumen perimeter on computed tomography (Pi10) and risk of first hospitalization or mortality due to chronic lower respiratory disease (CLRD) over fourteen years of follow-up in participants without prevalent clinical CLRD. The model is fully adjusted for age, sex, race/ethnicity, body mass index, smoking status, pack-years, percent emphysema, voxel size, and computed tomography scanner type.