Figure 2.

Copper (δ⁶⁵Cu) and Zinc (δ⁶⁶Zn) Isotopic Variability in Cerebrospinal Fluids

(A and B) (A) Copper (δ⁶⁵Cu) and (B) zinc (δ⁶⁶Zn) isotopic compositions measured in CSFs of CTRL (yellow dots), patients with AD (red dots), and patients with ALS (green dots). Circle and square points are for male and female subjects, respectively. For each boxplot, the central mark is the median; the edges of the box are the first (i.e., 25^th percentiles) and the third quartiles (i.e., 75^th percentiles), respectively; and the points outside the boxes extend to the most extreme data points (i.e., not considered outliers). Significance level (i.e., p value) was determined using non-parametric “two-sided,” Wilcoxon-Mann-Whitney U tests. **p < 0.005, *p < 0.05.