Table 1.

Summary of Tau Peptides and Half-Lives in the iPSC-Derived Neurons

Peptide (Abbreviated)	Peptide (Full)	Domain	Am in o Acids	Intracellular Half-Life (Days)		N	Extracellular Half-Life (Days)		N
				Mean	SD		Mean	SD
QEFE	QEFEVMEDHAGTYGLGDR	N term	6–23	6.44	0.32	4	6.35	1.17	4
DHAGTY	DHAGTYGLG	N term	13–21	6.47	0.89	2	7.50	0.79	2
DQGGYT	DQGGYTMHQDQEGDTDAGLK	N term	25–44	5.09	0.36	2	3.69	N/A	1
0N	AEEAGIGDTPSLEDEAAGHVTQAR	0N	103–126	6.81	0.67	4	6.36	0.88	4
DTPSLE	DTPSLE	Mid	110–115	6.32	0.65	2	6.85	0.63	4
TPSL	TPSLPTPPTR	Mid	212–221	7.84	0.66	4	6.77	1.49	4
LQTA	LQTAPVPMPDLK	MTBR-N	243–254	6.45	0.71	4	6.64	0.85	2
IGST	IGSTENLK	MTBR-N	260–267	6.56	0.67	4	6.99	0.62	2
LDL 4R	LDLSNVQSK	4R	282–290	3.57	0.20	2	N/A	N/A	0
HVPGG 4R	HVPGGGSVQIVYK	4R	299–311	4.34	0.37	2	N/A	N/A	0
3R	VQIVYKPVDLSK	3R	306–317	6.98	0.72	4	7.34	0.94	4
DRVQSK	DRVQSKIGSL	MTBR-C	348–357	6.08	1.16	2	4.24	1.77	2
IGSL	IGSLDNITHVPGGGNK	MTBR-C	354–369	6.38	0.97	4	5.24	0.33	2
DTSPR	DTSPRHLSNVSSTGSI	Cterm	402–417	4.93	0.51	2	2.52	N/A	1
DSPQL	DSPQLATLA	Cterm	421–429	6.10	1.12	2	5.41	0.04	2
DEVSAS	DEVSASLAKQGL	Cterm	430–441	4.75	0.96	2	3.33	0.42	2
Mean all				5.95	1.11		5.68	1.62
Mean N term to MTBR-N (without DQGGY)				6.70	0.53		6.78	0.40
Mean MTBR-C				6.23	0.21		4.74	0.70
Mean C term				5.26	0.73		3.75	1.49

N/A, not available due to limit of detection; MTBR, microtubule-binding region; SD, standard deviation; N represents number of cell lines analyzed.