Table 3.
Summary of the Very Mild AD and Age-Matched, Cognitively Normal Controls and Their Tau SILK Measures
| Participant | Age | Sex | CDR | CDR-SB | Amyloid Status | Amyloid PETAV45 (SUVR) | AV-45 PET-SILK Interval (Month) | Tau PET AV-1451 (SUVR) | Tau PET-SILK Interval (Month) | FTR (Pools/Day) | Half-Life (Days) | CSF Tau Cone (pg/mL) | Tau Production Rate (pg/mL/day) | FTR CV% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 71 | F | 0.5 | 2 | – | 0.66 | 9.8 | 1.16 | -1.2 | 0.0323 | 21.5 | 772.2 | 24.9 | 10.9 |
| 2 | 72 | F | 0 | 0 | – | 0.76 | 7.9 | N/A | N/A | 0.0219 | 31.7 | 734.6 | 16.1 | 11.3 |
| 3 | 78 | F | 0 | 0 | – | 0.80 | 29.6 | 1.37 | -10.4 | 0.0267 | 26.0 | 703.5 | 18.8 | 9.0 |
| 4 | 73 | F | 0.5 | 5 | – | 0.80 | 10.6 | 1.36 | 9.7 | 0.0268 | 25.8 | 599.6 | 16.1 | 13.3 |
| 5 | 77 | F | 0 | 0 | – | 0.85 | 45.9 | 1.12 | 1.6 | 0.0268 | 25.8 | 936.2 | 25.1 | 9.8 |
| 6 | 77 | M | 0 | 0 | – | 0.90 | 12.3 | 1.17 | 3.0 | 0.0165 | 42.1 | 940.4 | 15.5 | 10.5 |
| 7 | 76 | F | 0 | 0 | – | 0.91 | 43.1 | 1.26 | -0.7 | 0.0189 | 36.7 | 932.5 | 17.6 | 8.6 |
| 8 | 70 | F | 0 | 0 | – | 0.94 | 3.5 | 0.99 | 15.3 | 0.0252 | 27.6 | 874.4 | 22.0 | 10.8 |
| 9 | 79 | F | 0 | 0 | – | 1.06 | 9.0 | 1.23 | -0.9 | 0.0232 | 29.9 | 1079.6 | 25.0 | 12.2 |
| 10 | 87 | M | 0 | 0 | – | 1.07 | 9.9 | N/A | N/A | 0.0285 | 24.4 | 1349.8 | 38.4 | 8.0 |
| 11 | 75 | F | 0 | 0 | – | 1.08 | 13.0 | 0.97 | 19.0 | 0.0197 | 35.1 | 1057.3 | 20.9 | 9.1 |
| 12 | 81 | F | 0 | 0 | – | 1.17 | -7.5 | 1.31 | -6.2 | 0.0264 | 26.3 | 1282.6 | 33.9 | 9.6 |
| 13 | 75 | M | 0 | 0.5 | + | 1.44 | 43.2 | 1.08 | 0.4 | 0.0223 | 31.1 | 962.0 | 21.5 | 11.2 |
| 14 | 82 | F | 0.5 | 0 | + | 1.69 | 9.9 | 1.51 | 6.5 | 0.0267 | 25.9 | 1138.6 | 30.4 | 8.9 |
| 15 | 65 | M | 0 | 0 | + | 1.78 | 5.8 | 1.38 | 10.2 | 0.0210 | 33.1 | 1043.2 | 21.9 | 14.4 |
| 16 | 77 | F | 0.5 | 2.5 | + | 2.16 | 11.9 | 1.99 | 8.8 | 0.0195 | 35.5 | 1001.7 | 19.6 | 11.5 |
| 17 | 77 | M | 0 | 0 | + | 2.18 | 26.6 | 1.08 | 19.7 | 0.0235 | 29.5 | 1167.4 | 27.4 | 10.6 |
| 18 | 91 | M | 0.5 | 3.5 | + | 2.34 | 33.1 | 1.60 | 24.9 | 0.0187 | 37.0 | 1893.9 | 35.4 | 15.1 |
| 19 | 80 | F | 0.5 | 0 | + | 2.49 | 17.7 | 1.89 | -6.7 | 0.0260 | 26.7 | 1602.6 | 41.6 | 9.4 |
| 20 | 81 | F | 0 | 0 | + | 2.53 | 7.3 | 1.46 | 7.6 | 0.0228 | 30.4 | 947.7 | 21.6 | 15.2 |
| 21 | 90 | F | 0.5 | 2 | + | 2.87 | 14.2 | 1.67 | 11.8 | 0.0190 | 36.6 | 1464.0 | 27.8 | 12.4 |
| 22 | 81 | F | 0.5 | 1 | + | 3.25 | 18.3 | 1.80 | -5.2 | 0.0241 | 28.8 | 1258.1 | 30.3 | 10.2 |
| 23 | 68 | F | 0.5 | 0 | N/A | N/A | N/A | 1.24 | -7.1 | 0.0206 | 33.7 | 765.0 | 15.7 | 10.1 |
| 24 | 73 | M | 0.5 | 0 | N/A | N/A | N/A | N/A | N/A | 0.0190 | 36.6 | 1373.4 | 26.0 | 9.6 |
| Mean (amyloid -) | 76.3 | 0.1 | 0.6 | 0.9 | 15.6 | 1.2 | 2.9 | 0.0244 | 29.4 | 938.5 | 22.9 | 10.3 | ||
| SD | 4.7 | 0.2 | 1.4 | 0.2 | 15.8 | 0.1 | 8.8 | 0.0045 | 6.0 | 217.1 | 7.2 | 1.5 | ||
| Mean (amyloid +) | 79.9 | 0.3 | 1.0 | 2.3 | 18.8 | 1.5 | 7.8 | 0.0221 | 31.5 | 1247.9 | 27.8 | 11.9 | ||
| SD | 7.4 | 0.3 | 1.3 | 0.6 | 12.1 | 0.3 | 10.0 | 0.0028 | 4.0 | 313.2 | 7.0 | 2.3 | ||
| Mean (female) | 77.1 | 0.3 | 0.7 | 1.5 | 15.3 | 1.4 | 2.6 | 0.0238 | 29.6 | 1008.8 | 24.0 | 10.7 | ||
| SD | 5.6 | 0.3 | 1.4 | 0.9 | 14.2 | 0.3 | 8.8 | 0.0039 | 4.7 | 247.5 | 7.3 | 1.8 | ||
| Mean (male) | 77.8 | 0.1 | 0.6 | 1.6 | 25.3 | 1.3 | 11.7 | 0.0220 | 32.5 | 1247.2 | 26.4 | 11.2 | ||
| SD | 8.1 | 0.2 | 1.3 | 0.6 | 16.3 | 0.2 | 10.5 | 0.0041 | 6.0 | 323.7 | 7.5 | 2.6 | ||
| Mean | 77.3 | 0.2 | 0.7 | 1.5 | 17.1 | 1.4 | 4.8 | 0.0231 | 30.7 | 1078.3 | 24.7 | 10.9 | ||
| SD | 6.3 | 0.3 | 1.3 | 0.8 | 14.0 | 0.3 | 9.8 | 0.0039 | 5.1 | 306.1 | 7.3 | 2.0 |
CDR,value uptake tandardized s AV-45 of Cut-off available. not N/A, deviation; standard SD, rate; turnover positivity. Fractional tau for used FTR, was Box; of ratiocut-off CDR-Sum Nopositivity.CDR-SB,amyloidRating; for used Dementia was 1.22 Clinical =(SUVR)