Table 3.

Meta-analysis of the association between GDF5 rs143383 and musculoskeletal degenerative diseases

GDF5 rs143383	Subgroup	Assessment of association			Assessment of heterogeneity
		OR	95% CI	P	Pooling model	I2 (%)	P
Allelic model	Overall	1.32	1.19–1.48	0.000	Random	72.8	0.000
	Disease
	IDD	1.45	1.13–1.86	0.004	Random	67.6	0.005
	OA	1.28	1.14–1.44	0.000	Random	73.4	0.000
	Ethnicity
	Asian	1.49	1.25–1.77	0.000	Random	83.2	0.000
	Caucasian	1.18	1.09–1.28	0.000	Fixed	17.1	0.276
Homozygote model	Overall	1.80	1.49–2.16	0.000	Fixed	47.5	0.007
	Disease
	IDD	2.33	1.55–3.51	0.000	Fixed	29.5	0.203
	OA	1.67	1.36–2.05	0.000	Random	50.1	0.014
	Ethnicity
	Asian	2.28	1.71–3.05	0.000	Random	58.9	0.009
	Caucasian	1.46	1.23–1.74	0.000	Fixed	0.0	0.460
Heterozygote model	Overall	1.37	1.21–1.55	0.000	Fixed	26.7	0.122
	Disease
	IDD	1.84	1.34–2.52	0.000	Fixed	0.0	0.926
	OA	1.29	1.13–1.48	0.000	Fixed	38.4	0.065
	Ethnicity
	Asian	1.49	1.25–1.78	0.000	Fixed	15.5	0.300
	Caucasian	1.27	1.07–1.51	0.006	Fixed	33.8	0.120
Dominant model	Overall	1.56	1.39–1.75	0.000	Fixed	40.5	0.026
	Disease
	IDD	2.11	1.57–2.86	0.000	Fixed	0.0	0.569
	OA	1.46	1.29–1.66	0.000	Fixed	46.2	0.026
	Ethnicity
	Asian	1.82	1.54–2.16	0.000	Fixed	47.8	0.045
	Caucasian	1.35	1.15–1.58	0.000	Fixed	14.9	0.299
Recessive model	Overall	1.39	1.20–1.60	0.000	Random	73.3	0.000
	Disease
	IDD	1.44	1.02–2.04	0.037	Random	71.4	0.002
	OA	1.35	1.16–1.59	0.000	Random	74.0	0.000
	Ethnicity
	Asian	1.55	1.25–1.92	0.000	Random	83.2	0.000
	Caucasian	1.21	1.03–1.42	0.019	Fixed	36.2	0.101

IDD intervertebral disc degeneration, OA osteoarthritis, OR odds ratio, CI confidence interval