Figure 1 |. Evolutionary tumor dynamics under strong immune selection and a neoantigen fitness model based on immune interactions.

a, Clones are inferred from a tumor’s genealogical tree. We predict (𝜏), the future effective size of the cancer cell population, relative to its size at the start of therapy (equation (1)) by evolving clones under the model over a fixed time-scale, 𝜏. Application of therapy can decrease fitness of clones depending on their neoantigens. Clones with strongly negative fitness have greater loss of population size than more fit ones. b, Our model accounts for the presence of dominant neoantigens within a clone, α, by modeling presentation and recognition of inferred neoantigens, assigning fitness to a clone, F_α.