Table 5.
Frequencies of inferred haplotypes among the cases and controls and their association with risk of NIHL
| Haplotypes a | Case (n = 535*2) | Control (n = 535*2) | P b | Adjusted OR | Global P c | ||
|---|---|---|---|---|---|---|---|
| n | % | n | % | (95% CI) | |||
| GAC | 787 | 73.6 | 398 | 37.2 | 1.00 (Ref.) | < 0.001 | |
| GGC | 89 | 8.3 | 413 | 38.6 | < 0.001 | 0.11 (0.08–0.14) | |
| GGT | 7 | 0.7 | 221 | 20.7 | < 0.001 | 0.02 (0.01–0.03) | |
| AAC | 118 | 11.0 | 4 | 0.4 | < 0.001 | 14.95 (5.48–40.79) | |
| Others d | 69 | 6.4 | 34 | 3.2 | 0.972 | 1.01(0.66–1.55) | |
aThe alleles of haplotypes were arrayed as rs3124594-rs3124599-rs3124603
bTwo-sided χ2 test
cGenerated by permutation test with 1000 times of simulation
dHaplotypes with a frequency < 0.03 (AAC/AAT/AGT/GAT) were pooled into the mixed group