Table 1.
Overview of experiments used for the meta-analysis
| Exp. # | Person | WT/MUT (n) | Sex WT f/m MUT f/m (n) |
Rotarod (time(s)) WT mean (SD) Mut mean (SD) |
Open field (distance(m)) WT mean (SD) Mut mean (SD) |
Marble burying (# marbles buried) WT mean (SD) Mut mean (SD) |
Nest building (% material used) WT mean (SD) Mut mean (SD) |
Forced swim test (% floating) WT mean (SD) Mut mean (SD) |
|---|---|---|---|---|---|---|---|---|
| 1 | A | 15/13 | 8/7 6/7 |
128 (42) 96 (32) |
41 (14) 22 (11) |
11 (4) 4 (3) |
14 (25) 79 (18) |
53 (23) 83 (7) |
| 2 | A | 15/13 | 5/10 3/10 |
142 (43) 80 (32) |
49 (10) 32 (12) |
8 (4) 2 (3) |
36 (23) 79 (14) |
44 (24) 81 (7) |
| 3 | A | 15/13 | 5/10 3/10 |
133 (42) 92 (46) |
40 (12) 29 (8) |
11 (3) 2 (2) |
27 (18) 70 (18) |
41 (19) 73 (14) |
| 4 | B | 21/171) | 10/11 7/10 |
159 (60) 102 (36) |
31 (12) 19 (11) |
14(4) 4(5) |
10 (11) 48 (25) |
24 (22) 63 (18) |
| 5 | C | 9/112) | 5/4 6/5 |
163 (49) 91 (37) |
25 (6) 10 (7) |
12 (5) 4(5) |
48 (27) 69 (12) |
28 (24) 76 (8) |
| 6 | D | 15/143) | 4/11 6/8 |
107 (44) 74 (26) |
44 (7) 29 (13) |
12 (3) 3 (3) |
40 (18) 79 (12) |
14 (20) 60(31) |
| 7 | E | 15/15 | 8/7 7/8 |
196 (57) 126(52) |
45(10) 35 (7) |
11 (5) 6 (3) |
63 (20) 74 (14) |
47 (20) 67 (14) |
| 8 | A | 15/154) | 7/8 8/7 |
162 (49) 95 (35) |
49 (9) 33 (13) |
10 (3) 2 (3) |
N/A | 47 (20) 88 (9) |
All experiments were performed using Ube3atm1Alb mice in F1 hybrid 129S2-C57BL/6J background. For all tests shown in this table, we found a significant effect of genotype (p < 0.05), except for the nest building test of experiment 8, which was not performed. The table indicates the individual that performed the test battery, the number of wild-type and mutant mice used for each test, the number of females and males used for each experimental group, and the mean and standard deviation of the outcomes obtained. For the rotarod, we indicated the average performance over the 5 days, while for the nest building we provided the data as measured at day 5. Note that for some of the tests, we used a different number of mice (mice were not properly tracked, or a smaller cohort was used for nest building because of space limitations). The adapted n for these experiments is as follows: 1)nest building 13/12, forced swim test 20/17; 2)nest building 6/7; 3)open field 13/14; 4)open field 10/10, nest building not performed