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. 2018 Sep 14;19:324. doi: 10.1186/s12859-018-2347-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A phylogeny split into between- and within- cluster components. Sequences C01-1 and C01-2 belong to cluster 1, while C02-1, C02-2, and C02-3 belong to cluster 2. Sequence S01 is a singleton, that is, a cluster of size 1, and O is an outgroup, used to root the sample phylogeny. The red sub-phylogeny is called the between-cluster phylogeny, while the blue sub-phylogenies are called the within-cluster phylogenies