Table 2.
Allele frequencies and genotype distributions of ESR1 and ESR2 gene polymorphisms in the metabolic syndrome (MetS) and control groups
| Variables | MetS | Control | P | OR(95 % CI)a |
|---|---|---|---|---|
| n (%) | n (%) | |||
| (n = 150) | (n = 154) | |||
| ESR1 | ||||
| XbaI (A > G) | ||||
| A allele | 131 (43.7) | 171 (55.5) | ||
| G allele | 169 (56.3) | 137 (44.5) | 0.004 | 1.610 (1.169, 2.18) |
| 1 (AA) | 29 (19.3) | 45 (29.2) | ||
| 2 (AG) | 73 (48.7) | 81 (52.6) | 0.894 | 1.044 (0.556, 1.960) |
| 3 (GG) | 48 (32.0) | 28 (18.2) | 0.109 | 2.660 (0.874, 3.829) |
| PVUII (T > C) | ||||
| T allele | 143 (47.7) | 157 (52.3) | ||
| C allele | 158 (51.3) | 150 (48.7) | 0.223 | 1.219 (0.887, 1.676) |
| 1 (TT) | 31 (20.7) | 38 (24.7) | ||
| 2 (TC) | 79 (52.7) | 84 (54.5) | 0.012 | 2.440 (1.216, 4.897) |
| 3 (CC) | 40 (26.7) | 32 (20.8) | 0.038 | 2.288 (1.045, 5.009) |
| ESR2 | ||||
| RsaI (B5) (1082A > G) | ||||
| A allele | 101 (33.7) | 99 (32.1) | ||
| G allele | 199 (66.3) | 209 (67.9) | 0.689 | 1.071 (0.764, 1.503) |
| 1 (AA) | 20 (13.3) | 18 (11.7) | ||
| 2 (AG) | 61 (40.7) | 63 (40.9) | 0.863 | 1.074 (0.476, 2.426) |
| 3 (GG) | 69 (46.0) | 73 (47.4) | 0.834 | 0.851 (0.412, 2.044) |
| AluI (B8) (1730A > G) | ||||
| A allele | 100 (33.3) | 96 (31.2) | ||
| G allele | 200 (66.7) | 212 (68.8) | 0.568 | 1.104 (0.786, 1.552) |
| 1 (AA) | 21 (14.0) | 20 (13.0) | ||
| 2 (AG) | 58 (38.7) | 56 (36.4) | 0.225 | 0.592 (0.254, 1.382) |
| 3 (GG) | 71 (47.3) | 78 (50.6) | 0.172 | 0.567 (0.251, 1.281) |
Abbreviations: CI confidence interval, OR odds ratio, NA not available
OR OR value of rectified BMI and waist circumference for every allele
a95% of the 95% CI for the OR CI
p < 0.05 indicated statistical significance