Table 3.
Estimated haplotype distributions in the metabolic syndrome (MetS) and control groups
| SNP | Haplotype | MetS (freq.) | Control (freq.) | Global p-value | p-value |
|---|---|---|---|---|---|
| ESR1 | A-C | 65.15 (0.217) | 76.73 (0.249) | 0.022 | 0.351 |
| XbaI-PvuII | A-T | 65.85 (0.220) | 94.27 (0.306) | 0.015 | |
| G-C | 93.85 (0.313) | 71.27 (0.231) | 0.024 | ||
| G-T | 75.15 (0.250) | 65.73 (0.213) | 0.279 | ||
| ESR2 | A-A | 37.99 (0.127) | 25.20 (0.082) | 0.271 | 0.070 |
| 1082A > G-1730A > G | A-G | 63.01 (0.210) | 73.8 (0.240) | 0.383 | |
| G-A | 62.01 (0.207) | 70.8 (0.230) | 0.489 | ||
| G-G | 136.99 (0.457) | 138.20 (0.44) | 0.845 |
Abbreviation: SNP single-nucleotide polymorphism
Haplotypes have frequencies ≥3% in the MetS and control groups
p < 0.05 indicated statistical significance