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Acute toxicity LD50 and MTD (LD10) of vancomycin (1), eremomycin (2), and eremomycin pyrrolidide (5) in mice
| Parameter | Vancomycin (1) | Eremomycin (2) | Eremomycin pyrrolidide (5) |
|---|---|---|---|
| LD50 (mg/kg) | 525 (477.3÷577.5)* |
1,530.3 (1,172.3÷1,888.2)* |
248.4 (195.4÷301.4)* |
| MTD (LD10) (mg/kg) | 360 | 877.9 | 119.7 |
Note:
Data shown as mean LD50 (significant deviation of LD50 for P≥0.05).
Abbreviations: LD10, 10% lethal dose; LD50, 50% lethal dose; MTD, maximum tolerated dose.
