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. 2018 Sep 7;9:2046. doi: 10.3389/fimmu.2018.02046

Figure 2.

Figure 2

Combination of high HLA-A allele expression and HLA-B alleles mediating in robust “licensing” of NK cells result in strong NK cell inhibition and result in poor HIV control. (A) Less promoter methylation results in a high expression HLA-A (e.g., HLA-A*24). High HLA-A expression with the−21M genotype at HLA-B leads to increased cell surface expression of HLA-E, robust NK cell licensing through CD94/NKG2A increased inhibition of NK cells. Strong inhibition of NK cells leads to escape of HIV infected cells from NK mediated killing. (B) High promoter methylation results in low expression of HLA-A (e.g., HLA-A*03). Low expression HLA-A allele with−21T genotype at HLA-B results in lower HLA-E on the surface resulting in little CD94/NKG2A licensing, NK cells mediated killing HIV infected cells.