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. 2018 Sep 7;9:1006. doi: 10.3389/fphar.2018.01006

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Copyright © 2018 Sarno, Papulino, Franci, Andersen, Cautain, Melardo, Altucci and Nebbioso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of CHBH on cell cycle of HCT-116 and NB4 cells. (A) Chemical structure of CHBH; (B,C) FACS analysis showing that CHBH impairs cell cycle progression and induces cell death in HCT-116 and NB4 cells. The total amount of cells in G1, S, G2/M, and pre-G1 is 100%. Values are mean ± SD of biological triplicates.